Jiawei Xing

About Me

Hello, I'm Jiawei Xing, a computational biologist. I'm currently a postdoc in the Siepel lab at Cold Spring Harbor Laboratory. Before that, I received my PhD degree from the Jouline lab at The Ohio State University. My research interests are computational and evolutionary biology.

Education Background

2019 - 2023: The Ohio State University. PhD, Microbiology

2015 - 2019: Beijing Normal University. BS, Biological Sciences

Research Experiences

2024.3 - present: Postdoctoral researcher at Cold Spring Harbor Laboratory

Advisor: Dr. Adam Siepel
Probabilistic modeling on metastatic cancer lineage-tracing and single-cell transcriptomics

2021.1 - 2023.12: Graduate research assistant at The Ohio State University

Advisor: Dr. Igor Jouline
Understanding protein structures and evolution using phylogenetic analyses, biological networks, clustering algorithms, and hidden Markov models
Studying ligand-protein interactions using molecular docking and virtual ligand screening
Developing computational tools for bioinformatic analysis

2018.7 - 2018.10: Summer intern at IMCB, A*STAR, Singapore

Advisor: Dr. Yue Wang
Genome-wide screening of drug resistance genes in Candida albicans

Teaching Experience

2019.8 - 2020.12: Graduate teaching assistant at The Ohio State University

Professor: Dr. Mette Ibba
Labs for Basic and Practical Microbiology

Posters and Presentations

CSHL QB/AI In-house Seminar. Talk. Cold Spring Harbor, NY. Jun 2025
Biology of Genomes. Talk. Cold Spring Harbor, NY. May 2025
Probabilistic Modeling in Genomics. Poster. Cold Spring Harbor, NY. Mar 2025
CSHL Cancer In-house Seminar. Talk. Cold Spring Harbor, NY. Jan 2025
Bacterial Locomotion and Signal Transduction (BLAST) Conference. Talk (Best talk award for graduate students). Charleston, SC. Jan 2023
OSU Microbiology Department Annual Symposium. Talk. Columbus, OH. Dec 2022
Gordon Research Conference: Sensory Transduction in Microorganisms. Poster. Ventura, CA. Sep 2022
Bacterial Locomotion and Signal Transduction (BLAST) Conference. Poster. Online. Jan 2021
International Genetically Engineered Machine (iGEM) Competition. Talk and Poster. Boston, MA. Nov 2017

Certificates and Awards

Structure and evolution of protein sensory domains

Jouline lab

Probabilistic modeling of single-cell omics in cancer evolution

Siepel lab

Google Scholar

Sankhe GD, Xing J, Xiao M, Buglino JA, Li H, Zhulin IB, Glickman MS. Multi ligand sensing by a bacterial histidine kinase through inhibition of dimerization. bioRxiv. doi:https://doi.org/10.1101/2025.05.18.654591.
Velando F*, Xing J*, Genova R*, Cerna-Vargas JP, Vázquez-Santiago R, Matilla MA, Zhulin IB, Krell T. Chemoreceptor family in plant-associated bacteria responds preferentially to the plant signal molecule glycerol 3-phosphate. bioRxiv. doi:https://doi.org/10.1101/2024.12.10.627748.
Tajima Y, Vargas C, Ito K, Wang W, Luo JD, Xing J, Kuru N, Machado LC, Siepel A, Carroll TS, Jarvis ED, Darnell RB. A humanized NOVA1 splicing factor alters mouse vocal communications. Nat. Commun. 16, 1542 (2025). https://doi.org/10.1038/s41467-025-56579-2.
Monteagudo-Cascales E*, Gavira JA*, Xing J*, Velando F, Matilla MA, Zhulin IB, Krell T. Bacterial sensor evolved by decreasing complexity. Proc. Natl. Acad. Sci. U.S.A. 2025;122(5)e2409881122. doi:10.1073/pnas.2409881122.
Ruiz N, Xing J, Zhulin IB, Brautigam CA, Hendrixson DR. The Campylobacter jejuni BumS sensor phosphatase detects the branched short-chain fatty acids isobutyrate and isovalerate as direct cues for signal transduction. mBio. Published online December 13, 2024. doi:10.1128/mbio.03278-24
Xing J, Gumerov VM, Zhulin IB. Origin and functional diversification of PAS domain, a ubiquitous intracellular sensor. Sci Adv. 2023;9(35):eadi4517. doi:10.1126/sciadv.adi4517.
Demey LM*, Gumerov VM*, Xing J, Zhulin IB, DiRita VJ. Transmembrane Transcription Regulators Are Widespread in Bacteria and Archaea. Microbiol Spectr. 2023;11(3):e0026623. doi:10.1128/spectrum.00266-23.
Xing J, Gumerov VM, Zhulin IB. Photoactive Yellow Protein Represents a Distinct, Evolutionarily Novel Family of PAS Domains. J Bacteriol. 2022;204(11):e0030022. doi:10.1128/jb.00300-22. Editor's Pick.

* Equal contributions

Email: xing@cshl.edu

Address:
One Bungtown Rd, Cold Spring Harbor, NY 11724